Mammary breast cancer

Invasive mammary carcinoma, also known as infiltrating mammary carcinoma, is tumor that has features of both ductal carcinoma and lobular carcinoma. It is not two different cancers, just one that has features of both of the common types of breast cancer. At the Johns Hopkins Breast Center, our breast specialists understand how quickly patients want results from a biopsy or scan if there is a suspicion of breast cancer. We follow strict guidelines for biopsies and pathology reports.
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Diversity of Breast Carcinoma: Histological Subtypes and Clinical Relevance

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Understanding Your Pathology Report: Breast Cancer

The mammary gland is composed of a glandular ductal network. These ducts are lined by a protective layer of epithelial cells, and also contain myoepithelial cells that aid in contraction. The terminal duct-lobular unit, which makes up the terminal collecting duct within the breast is thought to be where breast cancer initiates. Laboratory models to study breast cancer include in vitro models using human breast cancer cells, as well as in vivo models, including genetic models or injection of breast cancer cells into the mammary fat pad. Since mammary epithelial cells respond to estrogen, it is important that our culture media is free of phenol red, which weakly activates the estrogen receptor, and may cause off-target signaling effects. Breast cancer is one of the most deadly cancers in women, and like all cancers, screening and detection of early stage disease is critical for good patient outcomes.
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Non-Invasive or Invasive Breast Cancer

Most often 80 percent of the time breast cancer begins in the milk ducts of the breast. If the abnormal cells have not broken through the duct into the surrounding breast tissue, it is called ductal carcinoma In situ DCIS. This means it has no ability to spread, as the abnormal cells are still confined to the duct. But, if the cancer cells have broken through the milk duct, and begin growing in the surrounding breast tissue, it is now called invasive mammary carcinoma, as it now has the ability to spread to the lymph nodes under the arm, and into the blood. Invasive mammary carcinoma is the most common type of breast cancer.
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They exhibit a wide scope of morphological features, different immunohistochemical profiles, and unique histopathological subtypes that have specific clinical course and outcome. Breast cancers can be classified into distinct subgroups based on similarities in the gene expression profiles and molecular classification. It usually has bad prognosis due to delays in diagnosis. Breast cancer occurs in any of the cells of the mammary gland and exhibits a wide scope of morphological features, different immunohistochemical profiles, and unique histopathological subtypes that have specific clinical course and outcome.
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